KNDy neuron role in increased heat dissipation caused by the lack of sex steroids in female and male rats
Vol 1, 2023 - 168389
Trabalho
Resumo
Hot flushes (FH) are a thermoregulatory disorder caused by reduced postmenopausal estradiol (E2) levels and characterized by peripheral vasodilation and increased heat dissipation. Kisspeptin, neurokinin B (NKB), and dynorphin (KNDy) neurons in the arcuate nucleus of the hypothalamus (ARC) facilitate heat dissipation in the absence of E2 in female rodents. Brainstem noradrenergic neurons project to KNDy neurons, which possibly plays a role in the HF genesis after E2 withdrawal.
Eixo Temático
- 6 - Sistema Endócrino
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