EVALUATION OF ENDOCANNABINOID SYSTEM’S INFLUENCE ON HUMAN REACTIVE ASTROGLIOSIS

Reactive astrogliosis is a process caused by extrinsic pathological signals and characterized by transcriptional, morphological and functional modifications in astrocytes. It may contribute to the maintenance or resolution of pathological conditions, making reactive astrocytes a potential pharmacological target. In addition, astrocytes participate in endocannabinoid signaling, which is essential for brain homeostasis and undergoes changes in several neurological diseases.