Congenital Zika virus infection impairs corpus callosum development

Congenital Zika Syndrome (CSZ) is a set of birth defects associated with Zika virus (ZIKV) infection during pregnancy. Infants may present with structural abnormalities such as microcephaly; ventriculomegaly; brain calcifications and dysgenesis of the corpus callosum. It is well described in the literature that ZIKV infects neural progenitors’ cells, causing cell cycle arrest and apoptosis which result in microcephaly. However, it remains unknown how ZIKV causes the other brain abnormalities in CSZ.