The role of melatonin on the heritable variation in the endocrine pancreas of the offspring of rats in hypomelatoninemia during pregnancy and lactation: Epigenetic influences on beta cell transdifferentiation

Vol 1, 2022 - 153715
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Resumo

In the fetus, maternal melatonin is responsible for coordinating organ and tissue development, plasticity and neuronal development, and metabolic programming. This study investigates the appearance of endocrine pancreas dysfunctions and metabolic disorders throughout the life of offspring generated in the absence of melatonin, and to assess the link between these findings and possible beta cell transdifferentiation and epigenetic changes. So far, we have observed that the absence of maternal melatonin during pregnancy and lactation promotes morphological and functional impairment in the endocrine pancreas of young male and female offspring. However, only in female offspring, maternal melatonin replacement can reverse the functional damage.

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Instituições
  • 1 Department of Physiology and Biophysics. Institute of Biomedical Sciences, University of São Paulo
  • 2 Department of Biochemistry, Institute of Chemistry, University of São Paulo
  • 3 Department of Physiology and Biophysics. Institute of Biomedical Sciences, University of São Paulo
  • 4 Department of Physiology. Federal University of São Paulo
Eixo Temático
  • Ciências Exatas, Naturais e da Vida
Palavras-chave
melatonin
Pancreatic islet
epigenetic
Offspring
GSIS