MRC-FAPESP cluster randomised controlled trial (RCT) for late life depression in socioeconomically deprived areas of São Paulo, Brazil

Vol 1, 2022 - 153700
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At 8-month follow-up, 63% (158/360) of the older adults who received the PROACTIVE psychosocial intervention recovered from depression (PHQ-9 score<10) compared with 44% (125/355) of those who received the enhanced usual care. The adjusted odds ratio for this difference was 2.08 (95% CI: 1.42, 3.03) after imputing missing values. These findings were maintained at 12 months. This innovative intervention delivered mainly by non-mental health professionals was effective to manage depression in primary care. If it is found to be cost-effective, the PROACTIVE intervention could be an option to help reducing the mental health treatment gap in low- and middle-income countries.

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  • 1 Departamento de Psiquiatria / Faculdade de Medicina FMUSP / Universidade de Sao Paulo
  • 2 Health Service and Population Research / Institute of Psychiatry, Psychology and Neuroscience / King's College London
  • 3 Health Research Institute / University of Limerick
  • 4 Health Economics Bristol / Population Health Sciences / Bristol Medical School / University of Bristol
  • 5 Population Health Sciences / Bristol Medical School / University of Bristol
  • 6 Instituto de Psiquiatria / Hospital das Clinicas HCFMUSP / Faculdade de Medicina / Universidade de Sao Paulo
Eixo Temático
  • Ciências Exatas, Naturais e da Vida
older adults
Collaborative care