Based on reliable property values, a framework for biodiesel process synthesis, design and simulation was created. To assess the capabilities of this framework, the biodiesel production from degummed oil and ethanol was taken as a process design case study. The process is synthesized based on a systematic methodology that uses knowledge and the thermodynamics insight theory to generate and evaluate process alternatives. A preliminary process design is proposed and simulated on COCO (CAPE-OPEN-to-CAPE-OPEN) process simulator confirming the contribution of this work as a tool for the application of process and product design techniques.