Process and product design are perhaps the chemical engineering quintessential activity mainly due to the many different aspects involved. Biodiesel is a very attractive alternative to fossil fuels regarding sustainability, but it requires economic efficient process in order to be widely implemented. Therefore, the application of systematic methods for process and product design is of special interest for biodiesel. However, the success of most systematic approaches for process and product design is based on reliable physical and chemical properties values. This work reports the computational implementation of property estimation methods specially developed and selected for biodiesel process related compounds into ChemSep™. The main advantage in this implementation is brought by the CAPE-OPEN capabilities of ChemSep™ that enables the use of reliable physical and chemical properties of more than 200 compounds in any process simulator that is CAPE-OPEN compliant