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Abstract

Rosmarinic acid (RA) is a commonly found phenolic compound with a well-documented neuroprotective effect. Nevertheless, besides the RA poor availability in central nervous system, some alternatives for RA delivery, protection, and release have been investigated by our research group. In this context, the present study aimed to evaluate the protective potential of chitosan-coated RA nanoemulsions (RA CNE) nasally administrated against neuroinflammation induced by lipopolysaccharide (LPS) in Wistar rats (protocol number 540/17). Animals were treated with RA CNE (2 mg.mL-1,100 µL per nostril) twice a day for six days. In the sixth day, LPS (250 µg.mL-1) was intraperitoneally administrated and 24 h after the animals were euthanized. RA brain quantification, objective recognition test and GFAP histochemical analysis were performed. Overall results demonstrated that RA CNE were able to protect against memory deficits and GFAP expression induced by LPS in Wistar rats, as soon as, facilitates the brain reach of RA.

Institutions
  • 1 Programa de Pós-Graduação em Ciências Farmacêuticas / Universidade Federal do Rio Grande do Sul
  • 2 Programa de Pós-Graduação em Biociências / Universidade Federal de Ciências da Saúde de Porto Alegre
  • 3 Programa de Pós-Graduação em Patologia / Universidade Federal de Ciências da Saúde de Porto Alegre
  • 4 Departamento de Bioquímica / Instituto de Ciências Básicas da Saúde / Universidade Federal do Rio Grande do Sul
Track
  • Nanotechnology
Keywords
rosmarinic acid
chitosan-coated nanoemulsions
neuroinflammation