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Rosmarinic acid (RA) is a commonly found phenolic compound with a well-documented neuroprotective effect. Nevertheless, besides the RA poor availability in central nervous system, some alternatives for RA delivery, protection, and release have been investigated by our research group. In this context, the present study aimed to evaluate the protective potential of chitosan-coated RA nanoemulsions (RA CNE) nasally administrated against neuroinflammation induced by lipopolysaccharide (LPS) in Wistar rats (protocol number 540/17). Animals were treated with RA CNE (2 mg.mL-1,100 µL per nostril) twice a day for six days. In the sixth day, LPS (250 µg.mL-1) was intraperitoneally administrated and 24 h after the animals were euthanized. RA brain quantification, objective recognition test and GFAP histochemical analysis were performed. Overall results demonstrated that RA CNE were able to protect against memory deficits and GFAP expression induced by LPS in Wistar rats, as soon as, facilitates the brain reach of RA.
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