12th International Conference of Pharmaceutical Sciences

Ion exchange resins are water-insoluble cross-linked polymers with ionizable functional groups1. These resins have been used to overcome different formulation-related problems such as taste masking or poor stability2,3,4. In this study, drug resinate of chloroquine (CLQ) and mefloquine (MFQ) salt forms, were prepared by the aqueous binding method, using Polacrilex (A), Sodium Polystyrene Sulfonate (B) and Polacrilin Potassium (C) resins under shaking for 3 hours. The influence of drug/resin ratio, time of complexation on drug loading rate and efficiency were explored. The UV analysis showed that Resin B presented the highest load efficiency with CLQ (89.4%) and resin C with MFQ (99.6%). However, resin A showed about 20% of drug load, which might be related to drugs adsorption on the resin surface. The results showed that CLQ and MFQ resinates are feasible, with high drug load efficiency and solvent-free process, having the qualities required for taste-masked formulations.