To cite this paper use one of the standards below:
Asthma is a chronic inflammatory disease of the lower airways. Chronic treatment mainly with corticosteroids may lead to the development of adverse effects. The species Eclipta prostrata (L.) L. is used by the population in Brazil for the treatment of respiratory diseases. The objective of this work was to evaluate the action of methanolic extract of E. prostrata in an ovalbumin-induced asthma model. Animals were sensitized (ip.) on days 1st and 8th and challenged with ovalbumin (intranasal) 3x week on 2nd, 3rd, 4th weeks and 4x times at 5th week. The treatment was performed with the extract (doses 250 and 500 mg Kg-1) for 7 days in 5th week. The bronchoalveolar lavage and the lungs were collected. Total and differential cell count demonstrated that treatment decreased pulmonary inflammation and eosinophilia in treated animals. The cytokines analysis showed that the extract decreases the production of Th2, IL-4 and IL-5. We conclude that the use of phytomedicines produced from E. prostrata is useful in asthma treatment.
With nearly 200,000 papers published, Galoá empowers scholars to share and discover cutting-edge research through our streamlined and accessible academic publishing platform.
Learn more about our products:
This proceedings is identified by a DOI , for use in citations or bibliographic references. Attention: this is not a DOI for the paper and as such cannot be used in Lattes to identify a particular work.
Check the link "How to cite" in the paper's page, to see how to properly cite the paper