12th International Conference of Pharmaceutical Sciences

Liquid crystalline systems allow the sustained drugs release, increasing their efficacy1,2. Thus, the aim of this study was to develop a liquid crystalline system based on murumuru butter (Astrocaryum murumuru). For the preparation of the formulations, the butter was melted (40°C). Then, the surfactant, water and metronidazole (MET) were added. From PLM analyzes, an adequate formulation was selected and the water uptake and in vitro drug release were performed. This formulation presented a hexagonal phase and captured around 45% of water, promoting a transition to a more viscous phase, suggesting an increase the drug retention on the mucosa. The analytical method recovered 102 ± 4.7% of MET. From in vitro drug release studies, MET diffused from solution (88%) until 2 h and from formulation (68.7%) until 12 h. Therefore, the liquid crystalline system based on murumuru showed a drug sustained release and potential use for the treatment of periodontal diseases.