12th International Conference of Pharmaceutical Sciences

Natural products, such as arthropod venoms, have been studied as sources of molecules for the development of new drugs for a wide range of diseases. In this sense, we previously demonstrated in an in vitro study that the Phoneutria nigriventer spider venom (PnV) is a potential source of antineoplastic candidates, primarily active in glioblastoma (GBM) cell lines1. Therefore, the aim of this study was to investigate the effects of PnV in the development of GBM in a murine model, evaluating tumor growth and immunomodulation. For this, human GBM cells (NG97) were inoculated into RAG-/- mice and PnV (14 μg/Kg) was administered every 48 h for 14 days. Results showed that the treatment impaired tumor growth, activated the systemic innate immune response and increased the number of tumor-infiltrating macrophages. These results suggest that the identification of the antineoplastic molecules from PnV may lead to a new multitarget chemotherapy to treat GBM.