Activity of nanocarriers for delivery and controlled release containing phthalocyanine derivatives to treat central nervous system neoplasms associated with photodynamic therapy

Vol. 1, 2019. - 116183
Favorite this paper
How to cite this paper?

According to the National Cancer Institute (INCA) in 2018 in Brazil cancers of the Central Nervous System (CNS) represent 17.22% of cancer mortality and are the most frequent solid tumors in the pediatric population, 20% of childhood neoplasms. The conventional treatment is surgical resection of the tumor and then radiotherapy and/or chemotherapy. To reduce this side effects, Photodynamic Therapy (PDT) appears as an alternative and complementary treatment for cancer. In this work we evaluated the effect of PDT with phthalocyanine-chloro-aluminum nanoemulsion (NE/AlClPc) on glioblastoma (U87MG and T98G) and medulloblastoma (UW473) cell lines. In the 24, 48, 72 and 96h periods, the cells lines presented the following cell viability percentages after the 700mJ/cm² dose (Figura 1). The PDT seems to be efficient in reducing cell and proliferative viability of this cell lines, which is promising for the treatment of regression of CNS tumors.

  • 1 Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo
  • 2 Química / Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto / Universidade de São Paulo
Central Nervous System
Photodynamic Therapy