12th International Conference of Pharmaceutical Sciences

According to the National Cancer Institute (INCA) in 2018 in Brazil cancers of the Central Nervous System (CNS) represent 17.22% of cancer mortality and are the most frequent solid tumors in the pediatric population, 20% of childhood neoplasms. The conventional treatment is surgical resection of the tumor and then radiotherapy and/or chemotherapy. To reduce this side effects, Photodynamic Therapy (PDT) appears as an alternative and complementary treatment for cancer. In this work we evaluated the effect of PDT with phthalocyanine-chloro-aluminum nanoemulsion (NE/AlClPc) on glioblastoma (U87MG and T98G) and medulloblastoma (UW473) cell lines. In the 24, 48, 72 and 96h periods, the cells lines presented the following cell viability percentages after the 700mJ/cm² dose (Figura 1). The PDT seems to be efficient in reducing cell and proliferative viability of this cell lines, which is promising for the treatment of regression of CNS tumors.