Proceedings of 10th Brazilian Symposium on Medicinal Chemistry

Handroanthus ochraceus is a medicinal plant used for malaria. Previous study showed furanonaphthoquinones as potential antimalarial compounds afforded from chloroformic active extract (inner stem bark).1 Other compounds have been identified from bark, but the other parts of this species have not been investigated so far.2,3 In this work, H. ochraceus ethanolic extract of bark revealed antimalarial potential and ethanolic extract from leaves revealed antimalarial and antileishmanial activities. Liquid chromatography-high resolution mass spectrometry (LC-HRMS) method was performed for compounds identification from leaves extracts allowing to identify nine compounds: quercetin-hexoside (1), forsythiaside I (2), luteolin (3), quercetin (4), trihydroxy-octadecenoic acid (5), alisol C (6), alisol B (7), palmitic acid (8) and betulinic acid (9). Betulinic acid (9) and quercetin (4) have showed in previous study antimalarial activity.4,5 Glycoside flavonoids such as quercitrin and its aglycone quercetin (4) are well known for reducing Leishmania sp. parasite in vitro and in vivo as well.6