New gluco-nitro-imidazoles, potential bioactive substances

The importance of carbohydrates in the proper functioning of the organism have been known for a long time. In medicinal chemistry, they have several appliications, as they can be associated with proteins (glycoproteins) and lipids (glycolipids). Thus, the field of research of glycol-compounds as enzyme inhibitors or transporters has been growing significantly, as the development of carbohydrate derivatives can therapeutically interfere with the metabolic processes of an individual in a pathological state. Another important therapeutic class is the nitro-nitroimidazoles, with 5-nitroimidazoles being responsible for its greatest therapeutic success, having several bioactive compounds, such as antiparasitic and antimicrobial. Therefore, it seemed interesting to us to prepare glyco-compounds containing a 5-nitroimidazole unit, to investigate their biological properties, such as against fungal biofilm. In this work, we performed the synthesis and characterization of glucometronidazole, obtained by non-classical glycosylation, performed by a click chemistry reaction, and evaluated its properties against fungal biofilms.