Design and synthesis of potential antichagasic agents

Chagas disease(CD) is a common anthropozoonosis in Latin America and its transmission occurs through the parasite called Trypanosoma cruzi. CD presents serious public health problems for many countries in Latin America. However, due to globalization and the legal and illegal immigration of people from endemic countries, several cases have been reported in other countries, such as the United States, Canada, Japan, and Australia, as well as in several European countries. Currently, in the 21 countries considered endemic, approximately 75 million people are exposed to the infection, six million are infected and more than 30,000 new cases arise each year. Faced with the need to search for molecules with antitrypanosomal activity, we have designed molecules based on nitric oxide releasers (NO) and enzymatic inhibition of CYP51 and Fe-SOD. Taking this into account, six compounds were synthesized and are now being analyzed for potential in vitro antitrypanosomal activity.