Proceedings of 10th Brazilian Symposium on Medicinal Chemistry

Dalbergia miscolobium Benth. (Fabaceae) is an endemic plant of Cerrado popularly known as “jacarandá-docerrado”. Species of this genus have secondary metabolites of class of flavonoids and different biological
activities such as antibacterial and antimalarial. In this work, D.
miscolobium was evaluated against P. falciparum using SYBR Green method. Crude extract of stem bark of D.
miscolobium revealed antiplasmodial activity, with an IC503D7 = 8.4 ± 0.4 μg/mL and SI of 16.9 ± 0.9. In order to
investigate the chemical profile of active extract, a method involving liquid chromatography-high resolution
quadrupole-time of flight mass spectrometry (LC-HRMS) was developed. By using Data Analysis 4.0 software and
Bruker Smart Formula and comparing to literature data, nine compounds were identified including tannin, flavonoid,
phenol, aromatic carboxylic acid and sesquiterpenoid class. Among compounds identified, similar compounds to benzoic
acid and procyanidin have revealed previously antimalarial potential.