9Th Brazilian Symposium on Medicinal Chemistry

Considering that some pathogenic fungal species have the ability to form biofilm and the treatment issues associated with this condition, we decided to synthesize new 8-hydroxyquinoline derivatives as potential antifungal and antibiofilm agents. Among the synthesized compounds, PH157 attracted attention; this compound was obtained through a two-step synthesis and evaluated against planktonic and sessile cells and biofilms of nine different strains of Candida spp.. The derivate exhibited promising results, presenting low MIC values for both cell types. In addition, it showed to be slightly more effective against planktonic compared to sessile cells. Regarding the biofilm assays, PH157 was able to inhibit or remove 50% of the biofilm at low concentrations. Finally, the results of PH157 were comparable or even superior to the drug fluconazole.