Indole-based Compounds are Endowed with Efficient Activity Against Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) is the main cause of an infection disease that has been reported as being among the top current causes of death resulting from a single pathogen.1 Our group has a great know-how in the development of quinoline-containing compounds active against Mtb. Using a molecular simplification approach, we decided to evaluate the indole ring as a possible scaffold group against Mtb. Applying Joucla’s procedure2 we synthesized a series of indoles arylated at the C-3 position. All compounds were tested against wild strain of Mtb (H37Rv) and the best one was tested against resistant strains showing good results that prompted us in the way to investigate its mechanism of action.