Fresh Insights of pharmacological profiling of Ru(II)-diphosphine complexes against ovarian cancer

- 341531
Short Presentation
Download
Favorite this paper
How to cite this paper?
Abstract

New ruthenium-based compounds have been designed as potential cytotoxic agents. These complexes have demonstrated significant cytotoxicity against different cancer cell lines, with the [Ru(dppm)2(PyS)]PF6 complex (1, dppm = 1,1'-bis(diphenylphosphine)methane) and PyS = 2-mercapto-pyridine) standing out due to its high cytotoxicity and selectivity for A2780 ovarian cancer cells. This complex affected cell morphology and induced significant cell damage in a dose-dependent manner, triggering apoptosis via ROS generation and mitochondrial damage. Our results revealed the ruthenium-phosphine-mercapto complex as a promising cytotoxic structure against ovarian cancer.

Share your ideas or questions with the authors!

Did you know that the greatest stimulus in scientific and cultural development is curiosity? Leave your questions or suggestions to the author!

Sign in to interact

Have a question or suggestion? Share your feedback with the authors!

Programme
17:45 to 17:55 on 09/14/2026
Room 1
Institutions
  • 1 Ufscar
  • 2 Universidade Federal de São Carlos | (Federal University of São Carlos)
  • 3 Universidade Federal de São Carlos
  • 4 Instituto de Física de São Carlos
Track
  • TL03 - Biological and Medicinal Inorganic Chemistry
Keywords
Ruthenium
Apoptosis
Ovarian cancer