Development of biomaterials integrating hybrid layered hydroxides and organic polymers

Layered inorganic materials with anion-exchange capabilities have gained significant attention as drug delivery systems (DDS) due to their unique structural and physicochemical properties. Their charged layers, tunable compositions, and high surface area enable controlled release of bioactive species, positioning them as strong candidates for therapeutic use. Layered double hydroxides (LDH) and layered hydroxide salts (LHS) have been validated in vitro as drug delivery systems. Biocompatibility was subsequently assessed in vivo. The combination of these inorganic nanoparticles with biocompatible polymers allows the development of multifunctional nanocomposites for drug delivery, including oral and transdermal applications, as well as tissue engineering for skin and bone therapies. This presentation discusses DDS of LDH or LHS intercalated with N-acetylcysteine, abietic acid, or naproxen. These hybrid materials were combined with silk fibroin, PEBAX (poly(tetramethylene oxide) and poly(amide)-12), or poly(lactic acid) to produce films, mats, or monoliths by solvent casting, electrospinning combined with electrospraying, or freeze-drying.