Unlocking Chemical Profiles of Ant Symbiotic Pseudonocardia: An Early Mass Spectrometry Approach

Vol 9, 2023 - 166776
Oral
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Abstract

This project studies the chemical profiles of Pseudonocardia cultures and their co-cultures with the specialized fungal pathogen Escovopsis, isolated from Amazonian fungus-growing ant colonies. Mass spectrometry analysis an at an early stage of our natural products research pipeline revealed fungal-induced bacterial metabolism changes. Despite close phylogenetic ties, these Pseudonocardia strains produce diverse bioactive compounds, impacting bioassays against Escovopsis and human pathogens.

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Institutions
  • 1 Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Universidade de São Paulo (USP)
  • 2 University of California - San Diego
Track
  • 9. Chemical Ecology
Keywords
Attine ants; microbial interactions; secondary metabolites; Mass Spectrometry; Molecular Networking