Synthesis and antimicrobial evaluation of new coumarin esters

Vol 9, 2023 - 167270
Poster
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Abstract

Highlights: Synthesis of 15 new coumarin esters, through a greener Steglich esterification methodology, using acetonitrile, three hydroxycoumarins and different carboxylic acids scaffolds. Evaluation on their potential as cytotoxic agents against alveolar epithelial cells of human adenocarcinoma (lineage A549), and as antimicrobial agents against Staphylococcus aureus ATCC43300 bacteria. Yields between 15% and 93%.

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Institutions
  • 1 Natural Products Research Group (GPPN), Chemistry Institute, UFBA, Salvador – Brazil
  • 2 Instituto Multidisciplinar de Saúde, UFBA, Vitória da Conquista – Brazil
Track
  • 7. Organic Synthesis and Structural Modification
Keywords
Coumarins; ESTERIFICATION; Antimicrobial activity