Polyketide synthases from Gymnopilus imperialis – A retro biosynthetic analysis connecting genomics with metabolomics

Vol 9, 2023 - 166580
Poster
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Abstract

This work aims to use genomics and metabolomics tools to identify biosynthetic gene
clusters through a “retro-biosynthetic” approach and heterologous express the genes involved in the biosynthesis of polyketide synthases using Aspergillus oryzae as a model organism.

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Institutions
  • 1 Universidade Federal de São Paulo
  • 2 Universidade de São Paulo
  • 3 Instituto Federal de Educação, Ciência e Tecnologia de São Paulo
  • 4 Westerdijk Fungal Biodiversity Institute
  • 5 Royal Netherlands Academy of Arts and Sciences (KNAW)
Track
  • 4. Biosynthesis and Molecular Biology of Natural Products
Keywords
BASIDIOMYCETES; genome mining; polyketides synthases; Heterologous Expression