Combining bioactivity-guided assays and LC-MS molecular networking to discover anti-trypanosomal molecules in a marine natural products library

Vol 9, 2023 - 167294
Oral
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Abstract

• Evaluation of the antiparasitic activity of a marine natural products library against T. brucei.
• Application of LC-MS molecular networking to discovery bioactive compounds.
• Cyclic and linear peptides were the main classes of metabolites with antiparasitic activity.
• Metabolites from cyanobacteria may be a source of new therapies to treat HAT.

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Institutions
  • 1 University of California San Diego
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
human African trypanosomiasis; parasite; Drug Discovery; Molecular Networking; marine natural products