Chemical characterization by LC-MS/MS of Ampelozizyphus amazonicus extracts with potential action on the Spike protein of SARS-CoV-2

Vol 9, 2023 - 166101
Poster
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Abstract

This work aimed to investigate the antiviral potential of Ampelozizyphus amazonicus, focusing on the inhibition of Spike protein and ACE2 receptor interaction, as well as the chemical characterization of the bark aqueous extracts through LC-MS/MS data. Aqueous (SARFLORA) extract of A. amazonicus bark was tested through in vitro immunoassay (Lumit® PROMEGA) and the fraction obtained with Methanol/H₂O 70:30% after the clean-up with XAD16® showed a 71% inhibition of the RDB:ACE2 interaction.

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Institutions
  • 1 Universidade Federal do Rio de Janeiro
  • 2 Universidade Federal da Paraíba
  • 3 Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro
Track
  • 1. Biodiversity and Natural Products
Keywords
Rhamnaceae; saponins; flavonoids; Coronavirus; Mass Spectrometry