Cell Death Induced by Dysregulation of Intracellular Copper Levels Carried by Biseugenol Isolated from Ocotea cymbarum (Lauraceae) in Breast Cancer

Vol 9, 2023 - 166995
Oral
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Abstract

Two neolignans (1 and 2) were isolated from O. cymbarum and effects of these compounds with Cu2+ were studied. Compound 2 was more cytotoxic than 1, however, when combined with Cu2+, 1 showed enhanced activity. Intracellular Cu levels increased significantly with 1 + Cu2+ combined, suggesting cell death through cuproptosis, a new and rare mechanism of cell death

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Institutions
  • 1 Universidade Federal do ABC
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
neolignans; Breast cancer; Copper Metabolism; Spheroids; ICP-MS