Bioactive extracts and annotation of compounds from the fungus Hypoxylon investiens using epigenetic modulators, Plackett-Burman design and Feature-Based Molecular Networking.

Vol 9, 2023 - 166199
Oral
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Abstract

H. investiens was cultivated using epigenetic modulators following a Plackett-Burman experimental design. The extracts were analyzed through feature-based molecular networking (FBMN) on the GNPS platform. Nine compounds were annotated, excluding those present in the growth medium. Some extracts exhibited cytotoxic and antifungal activities.

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Institutions
  • 1 Universidade Estadual Paulista “Júlio de Mesquita Filho”
  • 2 Universidade Estadual Paulista “Júlio de Mesquita Filho” - Campus Araraquara
  • 3 University of Sao Paulo
  • 4 Universidade de São Paulo
Track
  • 1. Biodiversity and Natural Products
Keywords
epigenetic; GNPS; Plackett-Burman DOE; cytotoxicity