A "Fleming" case study in the control of Penicillium digitatum, the causal agent of green mold on Citrus sinensis

This study presents an approach in microbial metabolomics based on high-resolution mass spectrometry associated with a co-cultivation strategy in the search for compounds capable of controlling the phytopathogen P. digitatum produced by LBQM02, a fungus found as contamination in our laboratory. Our results reinforce the hypothesis of the production of rare epipolythiodioxopiperazines (ETPs) by LBQM02 as being responsible for growth inhibition by fungistatic action observed in vitro.