Two Independently Evolved Clusters of Metabolic Genes Underpin First Steps of Hyperforin Biosynthesis in St. John’s wort

Vol 8, 2021 - 141873
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Abstract

Our main goal is to elucidate the biosynthesis of hyperforin in Hypericum perforatum. Two biosynthetic gene clusters encoding the first steps of hyperforin biosynthesis were discovered by genome mining. Functional characterization of genes in clusters led to a hyperforin precursor and a possible cryptic metabolite. Syntenic analysis revealed that the assembly of the two clusters is evolutionarily different.

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Institutions
  • 1 CAS Center for Excellence in Molecular Plant Sciences /University of Chinese Academy of Sciences
  • 2 CAS Center for Excellence in Molecular Plant Sciences
  • 3 Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden
  • 4 Institute of Genetics and Developmental Biology Chinese Academy of Sciences
Track
  • 4. Biosynthesis and Molecular Biology of Natural Products
Keywords
Hypericum perforatum
hyperforin
biosynthetic gene clusters
BIOSYNTHESIS
St John's Wort