Screening Program of Aqueous and Organic Extracts from Marine-Derived Fungi to Discover New Plasmodium falciparum Inhibitors

Vol 8, 2021 - 141366
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Abstract

Considerable antiplasmodial activities (Inhibition > 80% at 50 µg/mL) were observed for eight fungi strains (M3, M13, M15, M16, M20, M23, M28 and M30). Molecular networking analysis of all samples was used to quickly organize the data and investigate the secondary metabolite diversity. The integration of Feature-Based Molecular Networking and biological assays is an attractive strategy for selection of promising natural products as candidates for identification of new antiplasmodial agents.

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Institutions
  • 1 Universidade de São Paulo
Track
  • 1. Biodiversity and Natural Products
Keywords
marine-derived fungi
antiplasmodial
Molecular Networking