Mass spectrometry based metabolomics strategies to explore the anti-inflammatory metabolites of the Ocotea genus (Lauraceae)

Vol 8, 2021 - 142514
Oral
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Abstract

• A rapid UPLC-qTOF-MS method was developed for metabolite annotation and Ocotea genus metabolomics research.
• Anti-inflammatory bioactive makers were accessed through ex-vivo PGE2 release inhibition by UHPLC-MS/MS quantification.
• Multivariate Statistical Analysis indicated aporphine alkaloids as the main compounds correlated with the anti-inflammatory activity.

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Institutions
  • 1 Universidade Federal de Alfenas
  • 2 Universidade de São Paulo
  • 3 Universidade Federal de Juiz de Fora
  • 4 Waters
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
Multivariate statistical analyses
PGE2 inhibition
Bioactivity marker
UHPLC-qTOF