Chemical Approach of Schwartzia brasiliensis Choisy and its Potential Use Against the Toxic Effects of Bothrops jararaca and B. jararacussu Venom

Vol 8, 2021 - 142521
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Abstract

Aqueous residue after partition of Schwartzia brasiliensis Choisy ethanol leaf extract inhibited coagulant, hemolytic, proteolytic, hemorrhagic, edematogenic, and lethal activities of both Bothrops jararaca and B. jararacussu venoms, regardless of whether the sample was administered/incubated together with the venoms or after them. Moreover, some administration routes (intravenous, oral and subcutaneous) were investigated. The sample showed no toxicity to mice and red blood cells.

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Institutions
  • 1 Fundação Oswaldo Cruz
  • 2 Universidade Federal Fluminense
  • 3 Fundação Ezequiel Dias
  • 4 Universidade Federal do Rio de Janeiro
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
Schwartzia brasiliensis
Snake venom
Bothrops jararaca
Bothrops jararacussu