Chemical and biological integrated approaches for discovering anti-leukemia metabolites from Penicillium setosum

Vol 8, 2021 - 143004
Oral
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Abstract

Dereplication based approaches guided the identification of anthraquinones, liquenxantones and diketopiperazines not previously detected in Penicillium setosum. Some of these metabolites were isolated and submitted to anti-leukemia assays. Fellutanine C presented promising activity against leukemia cell lines (Kasumi-1) and this compound had its mechanism of action fully elucidated.

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Institutions
  • 1 Universidade Federal de São Paulo
  • 2 Universidade Federal de Mato Grosso do Sul
Keywords
Dereplication
Molecular Network
Leukemia
Penicillium setosum
Swinglea glutinosa