Chemical and biological integrated approaches for discovering anti-leukemia metabolites from Penicillium setosum

Vol 8, 2021 - 143004
Oral
Download
Favorite this paper
How to cite this paper?
Abstract

Dereplication based approaches guided the identification of anthraquinones, liquenxantones and diketopiperazines not previously detected in Penicillium setosum. Some of these metabolites were isolated and submitted to anti-leukemia assays. Fellutanine C presented promising activity against leukemia cell lines (Kasumi-1) and this compound had its mechanism of action fully elucidated.

Share your ideas or questions with the authors!

Did you know that the greatest stimulus in scientific and cultural development is curiosity? Leave your questions or suggestions to the author!

Sign in to interact

Have a question or suggestion? Share your feedback with the authors!

Institutions
  • 1 Universidade Federal de São Paulo
  • 2 Universidade Federal de Mato Grosso do Sul
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
Dereplication
Molecular Network
Leukemia
Penicillium setosum
Swinglea glutinosa