Bioprospection of Cerrado plants to Discover New Plasmodium falciparum Inhibitors as Lead Candidates for Malaria

Vol 8, 2021 - 140042
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Abstract

This work aims at discovering new Plasmodium falciparum inhibitors from Cerrado plants as lead compounds candidates for malaria. Ethanolic extracts of 25 Cerrado plants, including the stem bark of Dalbergia miscolobium Benth. (Fabaceae)and Tabebuia ochracea ssp. Cham. Standl. (Bignoniaceae), and leaves of Pterodon pubescens Benth (Fabaceae), showed attractive parasite growth inhibition (IC503D7 ranged from 4 to 8.4 μg/mL) and promising selectivity index 16-20.

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Institutions
  • 1 Instituto de Química, Universidade Federal de Catalão
  • 2 Instituto de Física de São Carlos, Universidade de São Paulo
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
malária
Plasmodium falciparum
Cerrado
Inhibitor