Antitrypanosomal acetogenins from fruit peels of Porcelia macrocarpa (Annonaceae)

Vol 8, 2021 - 142621
e-Poster
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Abstract

As part of our continuous study concerning the antitrypanosomal metabolites from Brazilian plants, the present work reports the bioactivity-guided fractionation of MeOH extract from fruits peels of Porcelia macrocarpa. This approach afforded a mixture composed by acetylene and enediyne acetogenins, with EC50 of 21.5 µg/mL against trypomastigotes and EC50 of 11.7 µg/mL against amastigotes (SI = 17.1).

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Institutions
  • 1 Universidade Federal do ABC
  • 2 Universidade de São Paulo
  • 3 Adolfo Lutz
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
Porcelia macrocarpa
Trypanosoma cruzi
acetogenins
Enediyne