Antimicrobial resistance profile and detection of drug resistant and multidrug resistant strains of Proteus mirabilis isolated from chicken meat sold in butchers in Londrina - PR

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Although it is often described as a commensal enterobacteria, Proteus mirabilis can also be considered an opportunistic pathogen and an etiologic agent of human and animal infections. Its high frequency of isolation in chicken meat and its intrinsic resistance to antibiotics such as tetracycline, nitrofurantoin, polymyxin and colistin reveal concerns about a potential zoonotic risk, which is aggravated by the presence of resistant and multiresistant strains to antibiotics widely used in combats certain infections such as the human urogenital tract. Based on this, this study aimed to observe the resistance profile and identify the presence of drug- and multidrug resistant strains of P. mirabilis isolated from chicken meat sold in butcher shops in Londrina – PR. For this purpose, were studied 100 P. mirabilis strains isolated from chicken meat sold in butcher shops located in the north, south, east, west and center region of Londrina – PR.. The bacterial isolates were tested using the Kirby-Bauer disk-diffusion technique, using 20 antimicrobials (amoxicillin [AMC], ampicillin [AMP], cefalotin [CFL], cefoxitin [CFO], ceftriaxone [CRO], ceftadizime [CAZ], cefepime [FEP], nalidixic acid [NAL], ciprofloxacin [CIP], norfloxacin [NOR], enrofloxacin [ENO], sulfamethoxazole [SUT], amikacin [AMI], gentamicin [GEN], chloramphenicol [CLO], aztreonam [ATM], ertapenem [ETP], tobramycin [TOB], ceftiofur [CTF] and fosfomycin [FOS]) with parameters from the Clinical and Laboratory Standards Institute (CLSI). In total, it was observed a resistance of 7% (AMC), 77% (AMP), 51% (CFL), 7% (CFO), 17% (CRO), 14% (CAZ), 17% (FEP), 91% (NAL), 47% (CIP), 38% (NOR), 89% (ENO), 89% (SUT), 0% (AMI), 19% (GEN), 17% (CLO), 4% (ATM), 0% (ETP), 18% (TOB), 17% (CTF) and 15% (FOS) in the strains tested. It was also observed that only 3 (3%) strains were sensitive to all antibiotics tested and 64 (64%) were resistant to ≥5 antibiotics, of which 7 (10.9%) of these exhibited resistance to ≥15 antibiotics. Based on these results, this work is further evidence of how chicken meat can act as reservoirs of drug- and and multi-drug resistant strains, a factor that when added to the potential pathogenicity of P. mirabilis demonstrates the danger to which consumers are exposed, making it essential the correct use of sanitation and disinfection techniques for butchery equipment in order to avoid both the spread of these organisms and the possibility of an outbreak of foodborne infections caused by resistant bacteria.

  • 1 Departamento de Microbiologia / Centro de Ciências Biológicas / Universidade Estadual de Londrina
  • 2 Universidade Estadual de Londrina
  • 3 Centro de Ciências Biológicas / Universidade Estadual de Londrina
  • 4 UNIFIL / Centro Universitário Filadélfia
  • Microbiologia de Alimentos
antimicrobial resistance